Quantum dots protect against MPP⁺-induced neurotoxicity in a cell model of Parkinson’s disease through autophagy induction

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• 作者：Lu Wang ; Xiaoming Li ; Yuping Han ; Ting Wang ; Yun Zhao…
• 关键词：quantum dots ; autophagy ; Parkinson’s disease ; α ; Synuclein ; Beclin1
• 刊名：SCIENCE CHINA Chemistry
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：59
• 期：11
• 页码：1486-1491
• 全文大小：813 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chinese Library of Science
  Chemistry
  
• 出版者：Science China Press, co-published with Springer
• ISSN：1869-1870
• 卷排序：59

文摘

Autophagy is a basic cellular process that decomposes damaged organelles and aberrant proteins. Dysregulation of autophagy is implicated in pathogenesis of neurodegenerative disorders, including Parkinson’s disease (PD). Pharmacological compounds that stimulate autophagy can provide neuroprotection in models of PD. Nanoparticles have emerged as regulators of autophagy and have been tested in adjuvant therapy for diseases. In this present study, we explore the effects of quantum dots (QDs) that can induce autophagy in a cellular model of Parkinson’s disease. CdTe/CdS/ZnS QDs protect differentiated rat pheochromocytoma PC12 cells from MPP+-induced cell damage, including reduced viability, apoptosis and accumulation of α-Synuclein, a characteristic protein of PD. The protective function of QDs is autophagy-dependent. In addition, we investigate the interaction between quantum dots and autophagic pathways and identify beclin1 as an essential factor for QDs-induced autophagy. Our results reveal new promise of QDs in the theranostic of neurodegenerative diseases.