Correlation of IL-27 genetic polymorphisms with the risk and survival of cervical cancer in a Chinese Han population
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- 作者：Jian Shi ; Meng Yuan ; Shuang Liu ; Xiaoyang Duan ; Juan Chen
- 刊名：Tumor Biology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：37
- 期：5
- 页码：6875-6879
- 全文大小：287 KB
- 刊物主题：Cancer Research;
- 出版者：Springer Netherlands
- ISSN：1423-0380
- 卷排序：37
文摘
Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties. However, there are no data about the role of IL-27 polymorphism in the development of cervical cancer. A hospital-based case–control study was conducted in 380 patients with cervical cancer and 380 healthy controls to investigate the possible associations of IL-27 gene polymorphisms (−964A/G, 2905T/G, and 4730T/C), with susceptibility to cervical cancer and clinical outcome. Our results suggested that the IL-27 2905T/G was significantly associated with a decreased risk of cervical cancer (TG vs. TT, odds ratio (OR) = 0.77; 95 % confidence interval (CI) = 0.60–0.86; GG vs. TT, OR = 0.95; 95 % CI = 0.72–0.96; TG+GG vs. TT, OR = 0.87; 95 % CI = 0.65–0.94). However, the genotype and allele frequencies of IL-27 (−964A/G and 4730T/C) polymorphisms in cervical cancer patients were not significantly different from controls. Further analysis showed IL-27 2905T/G genotypes were associated with advanced tumor stages of cervical cancer patients. More interestingly, the IL-27 2905T/G genotypes were statistically significantly associated with the survival in cervical cancer patients. Our results showed that the IL-27 2905T/G genotypes were associated with decreased susceptibility and development of cervical cancer in Chinese Han population.KeywordsIL-27Cervical cancerSingle nucleotide polymorphismSusceptibility