High-sensitive and temperature-self-calibrated tilted fiber grating biological sensing probe

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• 作者：Fu Liu (15724)
  Tuan Guo (15724)
  JianGuo Liu (25724)
  XiaoYang Zhu (35724)
  Yu Liu (35724)
  BaiOu Guan (15724)
  Jacques Albert (45724)
  
• 关键词：biosensor ; tilted fiber grating ; refractometer
• 刊名：Chinese Science Bulletin
• 出版年：2013
• 出版时间：July 2013
• 年：2013
• 卷：58
• 期：21
• 页码：2611-2615
• 全文大小：777KB
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• 作者单位：Fu Liu (15724)
  Tuan Guo (15724)
  JianGuo Liu (25724)
  XiaoYang Zhu (35724)
  Yu Liu (35724)
  BaiOu Guan (15724)
  Jacques Albert (45724)
  
  15724. Institute of Photonics Technology, Jinan University, Guangzhou, 510632, China
  25724. Institute of Semiconductors, Chinese Academy of Sciences, Beijing, 100083, China
  35724. Department of Biochemistry, Medical School, Jinan University, Guangzhou, 510632, China
  45724. Department of Electronics, Carleton University, Ottawa, K1S 5B6, Canada
  
• ISSN：1861-9541

文摘

High sensitivity biological sample measurement has been achieved by using a 10° tilted fiber Bragg grating sensing probe. Human acute leukemia cells with different intracellular densities were clearly discriminated by identifying their slight refraction index (RI) perturbations in the range from 1.3342 to 1.3344, combining with a temperature self-calibration property. We studied the relationship between the intracellular density of cells (S50 and S60) and their RIs, the experimental results provide a potential way to verify the hypothesis for “density alteration in non-physiological cells (DANCE)-