Quantitative magnetic resonance imaging (MRI) evaluation of cartilage repair after microfracture treatment for full-thickness cartilage defect models in rabbit knee joints: correlations with histological findings

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• 作者：Hongyue Tao ; Hong Li ; Yinghui Hua ; Zhongqing Chen ; Xiaoyuan Feng…
• 关键词：T2 mapping ; Microfracture ; Rabbit ; Histology
• 刊名：Skeletal Radiology
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：44
• 期：3
• 页码：393-402
• 全文大小：1,275 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Imaging and Radiology
  Orthopedics
  Pathology
  Nuclear Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2161

文摘

Objective To evaluate repair tissue (RT) after microfracture treatment for full-thickness cartilage defect models using quantitative MRI and investigate the correlations between MRI and histological findings. Materials and methods The animal experiment was approved by the Animal Care and Use Committee of our college. Thirty-six full-thickness cartilage defect models in rabbit knee joints were assigned to the microfracture or joint debridement group (as control). Each group consisted of 3-week, 5-week, and 7-week subgroups. MR imaging, including a three-dimensional double-echo steady-state sequence (3D-DESS), and T2 mapping were performed at 3, 5, and 7?weeks postoperatively. The thickness and T2 indices of RT were calculated. After MRI scans at each time point, operation sites were removed to make hematoxylin-eosin (H&E)-stained sections. Histological results were evaluated using the modified O’Driscoll score system. Comparisons were made between the two groups with respect to the MRI and histological findings, and correlation analysis was performed within each group. Results The thickness index and histological O’Driscoll score of RT in the two groups increased over time, while the T2 index decreased. The thickness index and histological O’Driscoll score of the microfracture group were higher than in the joint debridement group at each time point. The T2 index of the microfracture group was lower than in the joint debridement group at 3?weeks (P--.006), while it was higher than in the joint debridement group at 5 and 7?weeks (P--.025 and 0.025). The thickness index was positively correlated with the histological O’Driscoll score in both groups (microfracture: r s--.745, P--.001; joint debridement: r s--.680, P--.002). The T2 index was negatively correlated with the histological O’Driscoll score in both groups (microfracture: r s-??0.715, P--.002; joint debridement: r s-??0.826, P--.001). Conclusion Significant improvement over time after microfracture can be expected on the basis of the quantitative MRI finding and histological O’Driscoll score. MRI was correlated with the histological O’Driscoll score, which indicated that quantitative MRI 3D-DESS and T2 mapping could evaluate cartilage repair after microfracture as an effective noninvasive tool.