Studies on microRNAs that are correlated with the cancer stem cells in chronic myeloid leukemia

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• 作者：Xishan Zhu (1)
  Ziying Lin (1)
  Jing Du (2)
  Xu Zhou (1)
  Lawei Yang (1)
  Gang Liu (1)
  
• 关键词：microRNAs ; Cancer stem cells ; Chronic myeloid leukemia (CML)
• 刊名：Molecular and Cellular Biochemistry
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：390
• 期：1-2
• 页码：75-84
• 全文大小：827 KB
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• 作者单位：Xishan Zhu (1)
  Ziying Lin (1)
  Jing Du (2)
  Xu Zhou (1)
  Lawei Yang (1)
  Gang Liu (1)
  
  1. Clinical Research Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China
  2. Department of Urology, Weifang Traditional Chinese Medicine Hospital, Weifang, China
  
• ISSN：1573-4919

文摘

Accumulating data indicate that cancer stem cells play an important role in tumorigenesis and are underlying cause of tumor recurrence and metastasis, specifically in chronic myeloid leukemia (CML). We aim to detect the miRNAs that are correlated with the cancer stem cells in CML to provide theoretical basis for clinical application. We first analyzed microRNA expression profiles of CML leukemia patients compared with normal controls by microarray analysis and validated the results by real-time PCR. A single microRNA signature classified CML from normal was detected. We also determined the absolute copy numbers of these three microRNAs in normal adults. The results showed that three microRNAs (miR-150, miR-23a, and miR-130a) were identified to significantly decrease in expanded 38 CML patients compared with 90 normal controls. Molecular and statistical analysis showed that the decreased microRNAs were significant in clinical analysis. All these results indicated that those three microRNAs could act as a tumor suppressor and their decreased expression might be one of the causes of leukemia. Accordingly, clarifying their regulatory mechanisms might delineate their potentials as drug targets of gene therapy for CML.