Association between single nucleotide polymorphisms (SNPs) of XRCC2 and XRCC3 homologous recombination repair genes and triple-negative breast cancer in Polish women

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• 作者：Beata Smolarz ; Marianna Makowska ; Dariusz Samulak…
• 关键词：XRCC2 ; XRCC3 ; Triple ; negative breast cancer ; Gene polymorphism
• 刊名：Clinical and Experimental Medicine
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：15
• 期：2
• 页码：151-157
• 全文大小：368 KB
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• 作者单位：Beata Smolarz (1)
  Marianna Makowska (2)
  Dariusz Samulak (3) (4)
  Magdalena M. Michalska (3)
  Ewa Mojs (5)
  Maciej Wilczak (6)
  Hanna Romanowicz (7)
  
  1. Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother’s Memorial Hospital, Rzgowska 281/289, 93-338, Lodz, Poland
  2. Regional Hospital in Lodz, Lodz, Poland
  3. Department of Obstetrics and Gynaecology, Regional Hospital in Kalisz, Kalisz, Poland
  4. Cathedral of Mother’s and Child’s Health, Poznan University of Medical Sciences, Poznan, Poland
  5. Department of Clinical Psychology, Poznan University of Medical Sciences, Poznan, Poland
  6. Department of Medical Education, Poznan University of Medical Sciences, Poznan, Poland
  7. University of Computer Sciences and Skills, Lodz, Poland
  
• 刊物主题：Internal Medicine; Hematology; Oncology;
• 出版者：Springer Milan
• ISSN：1591-9528

文摘

XRCC2 and XRCC3 genes involved in homologous recombination repair (HRR) of DNA and in the maintenance of the genome integrity play a crucial role in protecting against mutations that lead to cancer. The aim of the present work was to evaluate associations between the risk of triple-negative breast cancer (TNBC) and polymorphisms in the genes, encoding for two key proteins of HRR: XRCC2 Arg188His (c. 563 G>A; rs3218536, Genbank Accession Number NT 007914) and XRCC3 Thr241Met (c. 722 C>T; rs861539, Genbank Accession Number NT 026437). The polymorphisms of the XRCC2 and XRCC3 were investigated by PCR–RFLP in 70 patients with TNBC and 70 age- and sex-matched non-cancer controls. In the present work, a relationship was identified between XRCC2 Arg188His polymorphism and the incidence of triple-negative breast cancer. The 188His allele and 188His/His homozygous variant increased cancer risk. An association was confirmed between XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms and TNBC progression, assessed by the degree of lymph node metastases and histological grades. In conclusion, XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be regarded as predictive factors of triple-negative breast cancer in female population.