The over-production of TNF-α via Toll-like receptor 4 in spinal dorsal horn contributes to the chronic postsurgical pain in rat

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• 作者：Yang Sun ; Mingmin Yang ; Hao Tang ; Zhongfu Ma ; Yanbing Liang…
• 关键词：TLR4 ; Chronic postsurgical pain ; TNF ; α ; SMIR
• 刊名：Journal of Anesthesia
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：29
• 期：5
• 页码：734-740
• 全文大小：1,658 KB
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• 作者单位：Yang Sun (2)
  Mingmin Yang (2)
  Hao Tang (1)
  Zhongfu Ma (1)
  Yanbing Liang (1)
  Zhenyu Li (1)
  
  2. Department of Pain, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, Xinjiang, 830054, China
  1. Department of General Internal Medicine, The First Affiliated Hospital of Sun Yat-sen University, Sun Yet-Sen University, 58 Zhongshan Rd. 2, Guangzhou, 510080, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Anesthesiology
  
• 出版者：Springer Japan
• ISSN：1438-8359

文摘

Purpose Many patients suffer from chronic postsurgical pain (CPSP) following surgery, and the underlying mechanisms are poorly understood. In the present work, using the skin/muscle incision retraction (SMIR) model, the role of spinal TLR4/TNF-α pathway in the induction of CPSP was evaluated.