参考文献:Ambros V (2004) The functions of animal microRNAs. Nature 431:350–355CrossRef PubMed Amit D, Tamir S, Birman T, Gofrit ON, Hochberg A (2011) Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of IGF2-P3 and IGF2-P4 regulatory sequences. Int J Clin Exp Med 4:91–102PubMedCentral PubMed Andrews WJ, Brown ED, Dellett M, Hogg RE, Simpson DA (2015) Rapid quantification of microRNAs in plasma using a fast real-time PCR system. Biotechniques 58:244–252PubMed Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281–297CrossRef PubMed Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar VR, Andersen MR et al (2005) Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33:e179PubMedCentral CrossRef PubMed Concannon CG, Tuffy LP, Weisova P, Bonner HP, Davila D, Bonner C, Devocelle MC, Strasser A, Ward MW, Prehn JH (2010) AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis. J Cell Biol 189:83–94PubMedCentral CrossRef PubMed Dai Y, Grant S (2015) BCL2L11/Bim as a dual-agent regulating autophagy and apoptosis in drug resistance. Autophagy 11:416–418CrossRef PubMed Frank DO, Dengjel J, Wilfling F, Kozjak-Pavlovic V, Hacker G, Weber A (2015) The pro-apoptotic BH3-only protein Bim interacts with components of the translocase of the outer mitochondrial membrane (TOM). PLoS One 10:e0123341PubMedCentral CrossRef PubMed Fujita T (2009) Gastric cancer. Lancet, 374:1593–1594; author reply 1594–1595 Ge Y, Zhao K, Qi Y, Min X, Shi Z, Qi X, Shan Y, Cui L, Zhou M, Wang Y et al (2013) Serum microRNA expression profile as a biomarker for the diagnosis of pertussis. Mol Biol Rep 40:1325–1332CrossRef PubMed Hagenbuchner J, Kuznetsov A, Hermann M, Hausott B, Obexer P, Ausserlechner MJ (2012) FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3. J Cell Sci 125:1191–1203CrossRef PubMed Hartgrink HH, Jansen EP, van Grieken NC, van de Velde CJ (2009) Gastric cancer. Lancet 374:477–490PubMedCentral CrossRef PubMed Hohenberger P, Gretschel S (2003) Gastric cancer. Lancet 362:305–315CrossRef PubMed Huang C, Li J, Hong K, Xia Z, Xu Y, Cheng X (2015) BH3-only protein Bim is upregulated and mediates the apoptosis of cardiomyocytes under glucose and oxygen-deprivation conditions. Cell Biol Int 39:318–325CrossRef PubMed Kilbride SM, Farrelly AM, Bonner C, Ward MW, Nyhan KC, Concannon CG, Wollheim CB, Byrne MM, Prehn JH (2010) AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF. J Biol Chem 285:36199–36206PubMedCentral CrossRef PubMed Li J, Zhang Y, Liu Y, Dai X, Li W, Cai X, Yin Y, Wang Q, Xue Y, Wang C et al (2013) Microvesicle-mediated transfer of microRNA-150 from monocytes to endothelial cells promotes angiogenesis. J Biol Chem 288:23586–23596PubMedCentral CrossRef PubMed Li Y, Peng T, Li L, Wang X, Duan R, Gao H, Guan W, Lu J, Teng J, Jia Y (2014) MicroRNA-9 regulates neural apoptosis in methylmalonic acidemia via targeting BCL2L11. Int J Dev Neurosci 36:19–24CrossRef PubMed Li J, Zhang Y, Li D, Liu Y, Chu D, Jiang X, Hou D, Zen K, Zhang CY (2015) Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression. Protein Cell 6:391–396PubMedCentral CrossRef PubMed Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433:769–773CrossRef PubMed Lin SC, Liu CJ, Lin JA, Chiang WF, Hung PS, Chang KW (2010) miR-24 up-regulation in oral carcinoma: positive association from clinical and in vitro analysis. Oral Oncol 46:204–208CrossRef PubMed Lin XJ, Chong Y, Guo ZW, Xie C, Yang XJ, Zhang Q, Li SP, Xiong Y, Yuan Y, Min J et al (2015) A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested case-control study. Lancet Oncol 16:804–815CrossRef PubMed Liu R, Zhang C, Hu Z, Li G, Wang C, Yang C, Huang D, Chen X, Zhang H, Zhuang R et al (2011) A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis. Eur J Cancer 47:784–791CrossRef PubMed Liu R, Chen X, Du Y, Yao W, Shen L, Wang C, Hu Z, Zhuang R, Ning G, Zhang C et al (2012) Serum microRNA expression profile as a biomarker in the diagnosis and prognosis of pancreatic cancer. Clin Chem 58:610–618CrossRef PubMed Liu YC, Zhao LM, Li DM, Yin Y, Zhang CY, Li J, Zhang YJ (2013) Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF, and the neutralization of miR-150 attenuate tumor development. Protein Cell 4:932–941CrossRef PubMed Luo S, Rubinsztein DC (2013) BCL2L11/BIM: a novel molecular link between autophagy and apoptosis. Autophagy 9:104–105PubMedCentral CrossRef PubMed Luo Y, Wang C, Chen X, Zhong T, Cai X, Chen S, Shi Y, Hu J, Guan X, Xia Z et al (2013) Increased serum and urinary microRNAs in children with idiopathic nephrotic syndrome. Clin Chem 59:658–666CrossRef PubMed Mansha M, Hussain A, Kofler A, Grubbauer C, Goetsch K, Ploner C, Kofler R (2013) “Bam,” a novel glucocorticoid-induced BH3-only transcript from the BCL2L11/Bim locus, does not appear to be translated. Leuk Lymphoma 54:353–358CrossRef PubMed Manyam BV, Mallick IH, Abdel-Wahab MM, Reddy CA, Remzi FH, Kalady MF, Lavery I, Koyfman SA (2015) The impact of preoperative radiation therapy on locoregional recurrence in patients with stage IV rectal cancer treated with definitive surgical resection and contemporary chemotherapy. J Gastrointest Surg 19:1676–1683CrossRef PubMed McBride SM, Raut CP, Lapidus M, Devlin PM, Marcus KJ, Bertagnolli M, George S, Baldini EH (2013) Locoregional recurrence after preoperative radiation therapy for retroperitoneal sarcoma: adverse impact of multifocal disease and potential implications of dose escalation. Ann Surg Oncol 20:2140–2147CrossRef PubMed Naito Y, Oue N, Pham TT, Yamamoto M, Fujihara M, Ishida T, Mukai S, Sentani K, Sakamoto N, Hida E et al (2015) Characteristic miR-24 expression in gastric cancers among atomic bomb survivors. Pathobiology 82:68–75CrossRef PubMed Organista-Nava J, Gomez-Gomez Y, Illades-Aguiar B, Del Carmen Alarcon-Romero L, Saavedra-Herrera MV, Rivera-Ramirez AB, Garzon-Barrientos VH, Leyva-Vazquez MA (2015) High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia. Oncol Rep 33:1639–1649PubMedCentral PubMed Qin W, Shi Y, Zhao B, Yao C, Jin L, Ma J, Jin Y (2010) miR-24 regulates apoptosis by targeting the open reading frame (ORF) region of FAF1 in cancer cells. PLoS One 5:e9429PubMedCentral CrossRef PubMed Tchernitsa O, Kasajima A, Schafer R, Kuban RJ, Ungethum U, Gyorffy B, Neumann U, Simon E, Weichert W, Ebert MP et al (2010) Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression. J Pathol 222:310–319CrossRef PubMed Tsukamoto Y, Nakada C, Noguchi T, Tanigawa M, Nguyen LT, Uchida T, Hijiya N, Matsuura K, Fujioka T, Seto M et al (2010) MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res 70:2339–2349CrossRef PubMed Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M et al (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103:2257–2261PubMedCentral CrossRef PubMed Wang C, Hu J, Lu M, Gu H, Zhou X, Chen X, Zen K, Zhang CY, Zhang T, Ge J et al (2015) A panel of five serum miRNAs as a potential diagnostic tool for early-stage renal cell carcinoma. Sci Rep 5:7610CrossRef PubMed Xiong HQ, Gunderson LL, Yao J, Ajani JA (2003) Chemoradiation for resectable gastric cancer. Lancet Oncol 4:498–505CrossRef PubMed Yin Y, Cai X, Chen X, Liang HW, Zhang YJ, Li J, Wang ZY, Chen XL, Zhang W, Yokoyama S et al (2014) Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth. Cell Resh 24:1164–1180CrossRef Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z, Sun F, Lu J, Yin Y, Cai X et al (2010) Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell 39:133–144CrossRef PubMed Zhang YQ, Li LM, Yu JX, Zhu DH, Zhang YJ, Li XH, Gu HW, Zhang CY, Zen K (2014) Microvesicle-mediated delivery of transforming growth factor beta 1 siRNA for the suppression of tumor growth in mice. Biomaterials 35:4390–4400CrossRef PubMed Zhang H, Yang H, Zhang C, Jing Y, Wang C, Liu C, Zhang R, Wang J, Zhang J, Zen K et al (2015) Investigation of microRNA expression in human serum during the aging process. J Gerontol A Biol Sci Med Sci 70:102–109CrossRef PubMed Zhao G, Liu L, Zhao T, Jin S, Jiang S, Cao S, Han J, Xin Y, Dong Q, Liu X et al (2015) Upregulation of miR-24 promotes cell proliferation by targeting NAIF1 in non-small cell lung cancer. Tumour Biol 36:3693–3701CrossRef PubMed Zhu D, Pan C, Li L, Bian Z, Lv Z, Shi L, Zhang J, Li D, Gu H, Zhang CY et al (2013) MicroRNA-17/20a/106a modulate macrophage inflammatory responses through targeting signal-regulatory protein alpha. J Allergy Clin Immunol 132(426–436):e428
作者单位:Haiyang Zhang (1) Jingjing Duan (1) Yanjun Qu (1) Ting Deng (1) Rui Liu (1) Le Zhang (1) Ming Bai (1) Jialu Li (2) Tao Ning (1) Shaohua Ge (1) Xia Wang (1) Zhenzhen Wang (3) Qian Fan (1) Hongli Li (1) Guoguang Ying (1) Dingzhi Huang (1) Yi Ba (1)
1. Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, 300060, China 2. Department of Gastroenterology, Tianjin First Center Hospital, Tianjin, 300192, China 3. Changchun GeneScience Pharmaceuticals Co., Ltd, Changchun, 130012, China
刊物主题:Biochemistry, general; Protein Science; Cell Biology; Stem Cells; Human Genetics; Developmental Biology;