文摘
Purpose To determine the correlation between intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters. Methods Thirty-eight newly diagnosed NPC patients were prospectively enrolled. Diffusion-weighted images (DWI) at 13 b-values were acquired using a 3.0-T MRI system. IVIM parameters including the pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f), DCE-MRI parameters including maximum slope of increase (MSI), enhancement amplitude (EA) and enhancement ratio (ER) were calculated by two investigators independently. Intra- and interobserver agreement were evaluated using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. Relationships between IVIM and DCE-MRI parameters were evaluated by calculation of Spearman’s correlation coefficient. Results Intra- and interobserver reproducibility were excellent to relatively good (ICC-em class="a-plus-plus">=-.887-0.997; narrow width of 95?% limits of agreement). The highest correlation was observed between f and EA (r--.633, P--.001), with a strong correlation between f and MSI (r--.598, P--.001). No correlation was observed between f and ER (r--0.162; P--.421) or D* and DCE parameters (r--.125-.307; P--.119). Conclusion This study suggests IVIM perfusion imaging using 3.0-T MRI is feasible in NPC, and f correlates significantly with EA and MSI. Key Points -Assessment of tumour perfusion is important in nasopharyngeal carcinoma. -DCE-MRI provided perfusion information with the use of intravenous contrast media. -Perfusion information could be provided by non-invasive IVIM MRI. -IVIM parameter f correlated with DCE-MRI parameters.