Detecting discordance enrichment among a series of two-sample genome-wide expression data sets
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- 作者：Yinglei Lai ; Fanni Zhang ; Tapan K. Nayak ; Reza Modarres ; Norman H. Lee…
- 关键词：Discordance ; Gene set enrichment ; Mixture models
- 刊名：BMC Genomics
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：18
- 期：1-supp
- 全文大小：4135KB
- 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
- 出版者：BioMed Central
- ISSN：1471-2164
- 卷排序：18
文摘
BackgroundWith the current microarray and RNA-seq technologies, two-sample genome-wide expression data have been widely collected in biological and medical studies. The related differential expression analysis and gene set enrichment analysis have been frequently conducted. Integrative analysis can be conducted when multiple data sets are available. In practice, discordant molecular behaviors among a series of data sets can be of biological and clinical interest.