KLF5, a new player and new target in the permanently changing set of pancreatic cancer molecular drivers

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• 作者：M. V. Zinovyeva ; M. B. Kostina ; I. P. Chernov…
• 关键词：pancreatic ductal adenocarcinoma ; KLF5 ; carcinogenesis ; master genes
• 刊名：Russian Journal of Bioorganic Chemistry
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：42
• 期：6
• 页码：606-611
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biochemistry, general; Bioorganic Chemistry; Organic Chemistry; Biomedicine general;
• 出版者：Pleiades Publishing
• ISSN：1608-330X
• 卷排序：42

文摘

Pancreatic cancer is one of the most aggressive tumor types characterized by chemotherapy resistance and high metastatic activity. Recent studies revealed new genes, which are likely to be actively involved in the regulation of the processes occurring in the pancreas, as well as in the development of cancer in this organ. This review is devoted to the description of one of the recently revealed genes, KLF5, which seems to be a promising target for therapeutic intervention in the most widespread type of pancreatic cancer, ductal adenocarcinoma.