• journal_title：Clay Minerals
• Contributor：M. Betsiou ; G. Bantsis ; I. Zoi ; C. Sikalidis
• Publisher：Mineralogical Society of Great Britain and Ireland
• Date：2011-
• Format：text/html
• Language：en
• Identifier：10.1180/claymin.2011.046.4.613
• journal_abbrev：Clay Minerals
• issn：0009-8558
• volume：46
• issue：4
• firstpage：613
• section：Articles

This investigation was carried out to determine whether the adsorptive and ion-exchange properties of faujasite (FAU) could be used to delivery locally the anticancer drugs gemcitanine hydrochloride (dFdU.HCl) and oxaliplatin (DACH-Pt). A soaking procedure was used for the determination of the maximum adsorption capacity of FAU and the mechanism described here was achieved. 274 mg dFdU.HCl/g FAU were adsorbed in 16 h, while 48 h were needed for the adsorption of 79.7 mg DACH-Pt/g FAU. Drug release studies were carried out by soaking the samples of loaded FAU in simulation body fluids (SBF). After only one hour 76% of dFdU.HCl was released while the release of DACH-Pt from the FAU was more normal since 38% of DACH-Pt was released in the first 24 h.