Twenty four species of Cancellariidae belonging to eleven genera occurring in the Neogene Bocas del Toro assemblages, Caribbean Panama, are discussed and figured. The following seven species are described as new: class="named-content genus-species" id="named-content-1">Cancellaria pilula n. sp., class="named-content genus-species" id="named-content-2">Cancellaria isabelae n. sp., class="named-content genus-species" id="named-content-3">Cancellaria stri n. sp., class="named-content genus-species" id="named-content-4">Cancellaria axelolssoni n. sp., class="named-content genus-species" id="named-content-5">Massyla corpulenta n. sp., class="named-content genus-species" id="named-content-6">Aphera trophis n. sp., class="named-content genus-species" id="named-content-7">Admetula valientensis n. sp. The cancellarid genus class="named-content genus-species" id="named-content-8">Charcolleria ref-ref-60-1" class="xref-bibr">Olsson, 1942 is considered a synonym of class="named-content genus-species" id="named-content-9">Massyla ref-ref-1-1" class="xref-bibr">H. Adams and A. Adams, 1854. Of the 24 species present in the Bocas del Toro, 12 are known also to occur elsewhere in the tropical American Neogene. This level of endemism is high, but not as high as that reported from other Tropical American Neogene assemblages, probably due to the very central geographic location within the Gatunian Province of the Bocas assemblages.