The effect of whole-grape powder on body composition,serum biomarkers of adipose tissue and bone metabolism in postmenopausal women.
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文摘
The effects of consuming freeze-dried,whole-grape powder (GP) or a placebo powder (P) for 12 weeks on body composition,biomarkers of inflammation,adipose tissue,and bone metabolism were determined. A randomized,double-blind,placebo-controlled study was performed with 40 post-menopausal women (mean age 52.4＋/-7.4) from 16 cities in Texas. Body composition and bone mineral densities (BMD) were determined using dual-energy X-ray absorptiometry (DXA). Serum concentrations of cross-linked N-telopeptide of type I collagen (NTX),alkaline phosphatase (ALP),osteocalcin (OC),insulin-like growth factor-1 (IGF-1),adiponectin,leptin,prostaglandin E2 (PGE2),and leukotriene E4 (LTE4) were assayed using enzyme-linked immunosorbent assays (ELISA). Participants' BMD were within normal ranges at baseline and at the end of study. NTX (p＝0.04) and ALP (p＝0.04) were significantly different between groups at baseline. In the P group (n＝14),OC (p＜0.01),adiponectin (p＝0.01),and LTE4 (p＝0.02) significantly decreased by 60.6%,45.8%,and 61.9%,respectively. OC (p＝0.02) and adiponectin (p＝0.02) significantly decreased in GP group (n＝11) by 50.9% and 59.7%,respectively. There were no significant differences between groups at 12 weeks. In the short-term,freeze-dried whole-grape powder may exert no favorable effects on bone or adipose tissue biomarkers in post-menopausal women. This research was funded and supported by California Table Grape Commission.