This case-control study involved 544 T2DM patients and 606 control subjects. Genotyping was done by the allelic exclusion method.
T allele of rs440960 (P = 6.5 脳 10鈭?) and C allele of rs1470579 (P = 5.3 脳 10鈭?) were significantly associated with T2DM; both SNPs were in strong LD (D鈥?#xA0;= 0.83, r2 = 0.58). While both IGF2BP2 SNPs were significantly associated with T2DM under additive and recessive models, only rs4402960 remained significantly associated with T2DM under the dominant model. Taking the common rs4402960/rs1470579 GA haplotype as reference, multivariate analysis confirmed the positive association of TC (P = 0.009; OR, 1.43; 95%CI, 1.09-1.87), and TA (P < 0.001; OR = 5.49; 95%CI = 2.09-14.39) haplotypes with increased T2DM risk. These differences remained significant after applying the Bonferroni correction for multiple testing.
We validate that IGF2BP2 susceptibility variants rs4402960 and rs1470579 associate with T2DM in Lebanese Arabs.