A total of 132 cases of T2DM and 135 cases of T2DM-CHD received intensive glucose therapy. After measuring left ventricular ejection fraction (LVEF) and the E/A ratio, variations and correlation factors were evaluated.
LVEF was significantly higher than before intensive therapy in the T2DM group with a glucose-lowering rate of 鈮? mmol路L-1路d-1 (P < .05). LVEF was significantly lower than before intensive therapy in the T2DM-CHD group with a glucose-lowering rate >4 mmol路L-1路d-1 (P < .05), whereas at the end of follow-up (3 months), LVEF increased and no significant difference was observed between subgroups (P > .05). The E/A ratio increased among all subgroups after intensive therapy (P < .05). The waist-hip ratio, duration of T2DM, and age had a linear regression relationship with variations in LVEF before and after intensive therapy.
For patients with T2DM and CHD, an excessively fast glucose-lowering rate could impair left ventricular systolic function. Long-term, good control of blood glucose could restore the impaired left ventricular systolic function caused by an excessively fast glucose-lowering rate. After intensive therapy, left ventricular diastolic function improved among all subgroups regardless of the glucose-lowering rate and CHD.