MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3

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• 作者：Na Huang^a ; ^{lala343@126.com} ; Jing Lin^a ; ^b ; ^{316603568@qq.com} ; Jian Ruan^a ; ^{12258276@qq.com} ; Ning Su^c ; ^{suning1983@gmail.com} ; Ruzhai Qing^a ; ^{761508475@qq.com} ; Feiye Liu^a ; ^{lfy406@yahoo.com} ; Benfu He^a ; ^{919970005@qq.com} ; Chengwei Lv^a ; ^{lvcwcn@yahoo.com.cn} ; Dayong Zheng^a ; ^{zhengdayong@hotmail.com} ; Rongcheng Luo^a ; ^{luorc01@163.com}
• 关键词：miR-219-5p ; Glypican-3 ; Hepatocellular carcinoma ; Cell proliferation ; miRNA
• 刊名：FEBS Letters
• 出版年：2012
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：23 March, 2012
• 卷：586
• 期：6
• 页码：884-891
• 文件大小：907 K

摘要

MicroRNAs (miRNAs) have been linked to the molecular pathogenesis of many cancers. In this study, we found that miR-219-5p was significantly downregulated in 83 HCC tissues and three HCC cell lines, compared to their non-tumor counterparts. MiR-219-5p expression correlated with tumor size, histological differentiation, and overall survival time in HCC patients. We also found that miR-219-5p could inhibit cell proliferation in vitro and arrest cell cycle at the G1 to S transition. Further studies identified that miR-219-5p reduced both the mRNA and protein levels of glypican-3 (GPC3). These findings indicate that miR-219-5p exerts tumor-suppressive effects in hepatic carcinogenesis through negative regulation of GPC3 expression.