Biphasic and Region-Specific MAO-B Response to Aging in Normal Human Brain

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• 作者：Saura ; J. ; André ; s ; N. ; Andrade ; C. ; Ojuel ; J. ; Eriksson ; K. ; Mahy ; N.
• 关键词：MAO A ; MAO B ; Aging human brain
• 刊名：Neurobiology of Aging
• 出版年：1997
• 期刊代码：202_01974580
• 类别：med
• 出版时间：September 10, 1997
• 卷：18
• 期：5
• 页码：497-507
• 文件大小：1.01 M

摘要

Variations of monoamine oxidases (MAO) A and B were studied during aging in 27 human subjects (age range 17–93 years) in 18 brain structures of temporal cortex, frontal gyrus, hippocampal formation, striatum, cerebellum, and brainstem. [³H]Ro41-1049 and [³H]lazabemide were used as selective radioligands to image and quantify MAO-A and MAO-B respectively by enzyme autoradiography. Postmortem delay or time of tissue storage did not affect MAO-A or MAO-B levels. There was, moreover, no evidence of sexual dimorphism. A marked age-related increase in MAO-B was observed in most structures. This increase started at the age of 50–60 years. Before this age, MAO-B levels were constant in all structures studied. MAO-B-rich senile plaques were observed in some cortical areas but they did not significantly influence the age-related MAO-B increase. Surprisingly, no age-related MAO-B changes were observed in the substantia nigra. In contrast to MAO-B, no clear age-related changes in MAO-A were observed, indicating an independent regulation of the two isoenzymes, also suggested by the cross-correlation analysis of these data.