• 作者：Enyu Imai ; Seiichi Matsuo
• 关键词：Nutrition ; Intensive care ; BMI ; NRI ; Transthyretin
• 刊名：The Lancet
• 出版年：2008
• 期刊代码：182_01406736
• 类别：med
• 出版时间：28 June 2008-4 July 2008
• 卷：371
• 期：9631
• 页码：2147-2148
• 文件大小：185 K

Findings

The national prevalence of chronic kidney disease was 11·93%(95%CI 11·66–12·28), but only 3·54%(3·37–3·68) of participants in the cohort were aware of their disorder. Prevalence was substantially higher in the group with low socioeconomic status than in the high status group (19·87%[19·84–19·91] vs 7·33%[7·31–7·35]). 56 977 (12%) of cohort participants had chronic kidney disease; those with disease had 83%higher mortality for all cause (HR 1·83 [1·73–1·93]) and 100%higher for cardiovascular diseases (2·00 [1·78–2·25]), in a cohort that was observed for 13 years with median follow-up of 7·5 years (IQR 4·0–10·1). 10·3%(95%CI 9·57–11·03) of deaths in the entire population were attributable to chronic kidney disease, but 17·5%(16·27–18·67) of deaths in the low socioeconomic status population. 2350 (39%) deaths occurred before 65 years of age in those with chronic kidney disease. Regular users of Chinese herbal medicines had a 20%(odds ratio 1·20 [1·16–1·24]) increased risk of developing chronic kidney disease.

Interpretation

The high prevalence of chronic kidney disease and its associated all-cause mortality, especially in people with low socioeconomic status, make reduction of this disorder a public-health priority. Promotion of its recognition through the general public knowing their glomerular filtration rate and testing their urine is crucial to reduce premature deaths from all causes and to attenuate this global epidemic.

Funding

None.