[11C]DAA1106 was prepared by O-[11C]methylation of DAA1123 with [11C]CH3OTf and NaH in CH3CN at 80 掳C and isolated by HPLC combined with SPE purification in 60-70%decay corrected radiochemical yield. [18F]FEDAA1106 was synthesized by the nucleophilic substitution of tosyloxy-FEDAA1106 in DMSO with K[18F]F/Kryptofix 2.2.2 at 140 掳C and isolated by HPLC combined with SPE purification in 30-60%decay corrected radiochemical yield. The specific activity for [11C]DAA1106 and [18F]FEDAA1106 was 370-740 GBq/渭mol and 37-222 GBq/渭mol at EOB, respectively.