Synthesis, ¹⁵N NMR spectra and GIAO calculated data of the seven positional isomers of ¹⁵N-labeled N,N-dimethylsulfamoylquinoline

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• 作者：Krzysztof Marciniec^a ; ^{kmarciniec@sum.edu.pl} ; Andrzej Maś ; lankiewicz^a ; Maria J. Maś ; lankiewicz^b ; Rafał ; Kurczab^c
• 关键词：15N NMR ; 15N-labeled N ; N-dimethylquinolinesulfonamides ; Chemical shifts of quinolinesulfonamides ; GIAO calculations
• 刊名：Journal of Molecular Structure
• 出版年：2012
• 期刊代码：62_00222860
• 类别：ch
• 出版时间：16 May, 2012
• 卷：1015
• 期：Complete
• 页码：46-50
• 文件大小：262 K

摘要

The one-step synthesis of positional isomers of N,N-dimethylsulfamoylquinoline are presented. Seven newly synthesized compounds have been characterized by elemental analyses, MS, ¹H and ¹⁵N NMR spectral data. The long-range correlations between the ring protons and the endocyclic nitrogen atoms were observed in the gHMBC experiments. The spectral positions of the nitrogen atoms from the sulfonamide groups were drawn from the 1D spectra of the ¹⁵N-labeled sulfonamide isotopomers. Correlations between the experimentally determined chemical shifts and GIAO calculated isotropic shielding constants were found. The GIAO calculations were based on HF-, MP2-, and B3LYP-optimized geometries and were performed at the HF, BLYP, and B3LYP levels of theory.