- 作者：L.S. Gó ; mez-Guerra ; A.U. Herná ; ndez-Torres ; A. Blanco-Guzmá ; n ; D.E. Solí ; s-Rodrí ; guez ; G.E. Ortiz-Lara ; J.R. Corté ; s-Gonzá ; lez<sup> ; sup><sup>drjeffrcortes@gmail.comsup>
- 关键词：Í ; ndice de masa corporal ; Antí ; geno prostá ; tico especí ; fico ; Cá ; ncer de pró ; stata ; Sobrepeso ; Obesidad
- 刊名：Actas Urol贸gicas Espa帽olas
- 出版年：2012
- 期刊代码：pca37_02104806
- 类别：med
- 出版时间：May, 2012
- 卷：36
- 期：5
- 页码：302-305
- 文件大小：573 K
ss="h4">Objective
To evaluate the effect of body mass index (BMI) on PSA in northeast Mexican patients included in prostate cancer (Pca) early detection screening campaigns offered by our institution.
ss="h4">Material and methods
One hundred and ninety seven patients came voluntarily to our Pca early detection screening campaigns. Exclusion criteria: PSA >10 ng/dl, patients on 5-伪 Reductase inhibitors or hormonal replacement. Overweight and obesity were considered when BMI was between 25-29.9 and 鈮?0 kg/m<sup>2sup> respectively. Simple linear and multiple regression were used in the statistical analysis. Mean and standard deviation were utilized to evaluate spread and normal distribution. P values <0.05 were considered statistically significant.
ss="h4">Results
One hundred and fifty two patients were included in this study. Forty four percent (83) and 30.3%(46) presented with overweight and obesity, respectively. Mean BMI was 28.16 kg/m<sup>2sup> (SD 1.77). A statistically significant negative effect of BMI on PSA was observed in the linear regression. This effect persisted when adjusted for age in the multiple regression model. A decrease of 0.085 ng/dl for every unit of BMI (p <0.001) was observed in the simple linear regression. This value was 0.07 in the multiple regression (p = 0.006)
ss="h4">Conclusions
A higher negative effect of BMI on PSA was found in comparison to published literature. A higher proportion of patients with BMI >25 kg/m<sup>2sup> than the national mean was observed. A multicentric national study is needed in order to challenge these results.