- 作者：J. Carrasco-Valiente<sup>asup><sup> ; sup><sup>juliacv83@hotmail.comsup> ; F.J. Anglada-Curado<sup>asup> ; P. Aguilar-Melero<sup>bsup> ; R. Gonzá ; lez-Ojeda<sup>bsup> ; J. Muntané ; -Relat<sup>bsup> ; F.J. Padillo-Ruiz<sup>csup> ; M.J. Requena-Tapia<sup>asup>
- 关键词：Litiasis renal ; Dañ ; o glomerular ; Estré ; s oxidativo
- 刊名：Actas Urol贸gicas Espa帽olas
- 出版年：2012
- 期刊代码：pca37_02104806
- 类别：med
- 出版时间：May, 2012
- 卷：36
- 期：5
- 页码：296-301
- 文件大小：892 K
ss="h4">Objective
This present study has aimed to assess the state of acute phase markers and oxidative stress in patients with kidney stones.
ss="h4">Material and methods
A prospective study was carried out on 100 patients with kidney stones and 25 healthy controls. Albumin, 脽2 microglobulin, Gamma-glutamyl transpepsidase, Lactate dehydrogenase, Tumor necrosis factor alpha, Interleukin 1 and Interleukin-6 were evaluated as acute phase markers and lipid peroxidation products, Superoxide dismutase and Glutathione peroxidase levels acted as oxidative stress markers.
ss="h4">Results
An increase in renal cell damage markers as expressed by the 脽2 microglobulin (p = 0.04), albumin (p = 0.004), Lactate dehydrogenase (p = 0.001) and Gamma glutamyl transpepsidasa (p = 0.01) was observed in the patient group. There was a direct correlation between levels of 脽2microglobulin and stone size (r = 0.3, p = 0.03). The association between stone size and cytokine activation was observed to be stronger in patients with staghorn calculi. In these patients, Tumor necrosis factor alpha (p = 0.011), Interleukin 1 (p = 0.004) and Interleukin 6 (p = 0.004) were significantly higher. Patients with stones in the urinary tract showed data of significantly higher oxidative stress, expressed as an increase in levels of lipid peroxidation products (p = 0.03) and a decrease in the antioxidant activity of Superoxide dismutase (p = 0.03) and Glutathione peroxidase (p = 0.002).
ss="h4">Conclusions
Patients undergoing urolithiasis showed an elevation of acute phase markers, associated with oxidative stress as expressed by an increase in lipid peroxidation products and a decrease in the antioxidant enzyme activity.