• 作者：S. Vilar-Gonzá ; lez^a ; ^{santiagov06@gmail.com} ; X. Maldonado-Pijuan^b ; I. André ; s-Garc&#237 ; a^c
• 关键词：Aná ; logos de la hormona liberadora de la hormona luteinizante ; Carcinoma prostá ; tico ; Carcinoma de pró ; stata ; Efecto de clase farmacoló ; gica ; Deprivació ; n androgé ; nica ; Medicina basada en la evidencia
• 刊名：Actas Urol贸gicas Espa帽olas
• 出版年：2010
• 期刊代码：pca37_02104806
• 类别：med
• 出版时间：October 2010
• 卷：34
• 期：9
• 页码：749-757
• 文件大小：233 K

Introduction

Evidence-based medicine is transforming clinical practice because of its progressive implantation.

Objectives

We considered studying whether LHRH analogues are agents of the same pharmacological class, i.e., whether they have the same clinical effect, using the approach to evidence-based medicine.

Material and methods

PubMed was used as the main source of search. We have reviewed the evidence on the alleged 芦drug class effect禄 between analogues and the existing bibliographic support for their use in various medical indications. An evidence level and degree of recommendation have been assigned to each conclusion based on the 芦Scottish Intercollegiate Guidelines Network禄.

Results

There are no studies designed to answer the question of a class effect between LHRH analogues or agonists. Reviews and meta-analyses have been performed on many other issues related to therapeutic management either with analogues, alone or in combination with surgery or radiation therapy. Direct comparisons do not allow for obtain definitive conclusions. Indirect evidence is obtained from randomized studies comparing the different LHRH analogues to other treatments used to obtain androgen deprivation. Other issues related to pharmacokinetics and pharmacodynamics supporting either the existence or non-existence of class effect were evaluated.

Conclusions

The current available evidence is not enough to support a presumed 芦drug class effect禄 among the various analogues in the treatment of prostate carcinoma.