• 作者：Jesú ; s Bellido-Casado^a ; ^{jbellido@santpau.cat} ; Vicente Plaza^a ; Cé ; sar Dí ; az^b ; Carme Geli^b ; José ; Domí ; nguez^a ; Gisela Margarit^c ; Montserrat Torrej&#243 ; n^a ; Jordi Giner^a
• 关键词：S&iacute ; ndrome de Sjö ; gren primario ; Tos cr&oacute ; nica ; Linfocitosis ; Esputo inducido
• 刊名：Archivos de Bronconeumolog铆a
• 出版年：2011
• 期刊代码：pca65_03002896
• 类别：med
• 出版时间：July 2011
• 卷：47
• 期：7
• 页码：330-334
• 文件大小：217 K

ass="h4">Introduction

There is no information available regarding the relationship between the respiratory symptoms or lung function and bronchial inflammation, measured by induced sputum.

ass="h4">Objectives

Description of the clinical characteristics, radiographic images and lung function of patients suffering from Primary Sj枚gren Syndrome (PSS), and to assess the relationship with the inflammatory airway profile.

ass="h4">Methods

We analysed clinical, radiology, lung function tests, bronchial hyperresponsiveness and inflammatory data in the induced sputum from 36 consecutive patients with PSS.

ass="h4">Results

A total of 58%of patients had hoarseness and 42%had cough and dispnea. No lung dysfunction was observed, although 46%(n = 16) had a positive bronchial response. Lymphocytosis >2.6%in induced sputum was observed in 69%of all sputa. There was chronic coughin 29%of patients with lymphocytosis (n = 24), whereas 73%were normal (n = 11) (P = .02). The duration time of cough was less for the former (P = .02). On the contrary a positive bronchial response was associated with lymphocytosis >2.6%(P = .02). Lipophages were presnt in 55%of pathological sputa (n = 22) (index >15) versus 18%of the non-pathological ones (n = 11) (P = .05).

ass="h4">Conclusion

Hoarseness, cough and dyspnea are frequent respiratory symptoms in PSS, although there is a wide variation in the relationship with bronchial responsiveness and airway inflammation. Lymphocytosis in the airways is another site of the infiltrative process in PSS, and the induced sputum is a complementary tool in the identification of active inflammatory process.