• 作者：Juan Bustamante^a ; ^{jbustamantemunguira@gmail.com} ; Eduardo Tamayo^b ; Santiago Fl&#243 ; rez^a ; Juan J. Telleria^c ; Elena Bustamante^b ; Javier L&#243 ; pez^d ; J. Alberto San Romá ; n^d ; F. Javier Á ; lvarez^e
• 关键词：Inmunidad innata ; Polimorfismo gen&eacute ; tico de un solo nucle&oacute ; tido ; Toll-like receptor 2 ; Endocarditis infecciosa
• 刊名：Revista Espa帽ola de Cardiolog铆a
• 出版年：2011
• 期刊代码：pca308_03008932
• 类别：med
• 出版时间：November 2011
• 卷：64
• 期：11
• 页码：1056-1059
• 文件大小：165 K

The ability to respond to the ligands of toll-like receptors (TLR) could be affected by single nucleotide polymorphisms in TLR codifying genes. The influence of the polymorphisms TLR2 (R753Q, R677W), TLR4 (D299G, T399I) and CD14 (C-159T) was consecutively studied in 65 patients with infective endocarditis. The control group (n=66) consisted of healthy volunteers. All the polymorphisms were genotyped by means of restriction analysis after their amplification. An association between endocarditis and variants of TLR2 R753Q (P <.001) was observed, but no association with other polymorphisms was found. The TLR2 R753Q co-dominant (odds ratio=13.33), recessive (odds ratio=9.12) and dominant (odds ratio=3.65) genotypes showed a positive association with the infective endocarditis phenotype. The polymorphism TLR2 R753Q was associated with a greater susceptibility towards the development of infective endocarditis. Further studies are required to validate these results and identify other genetic risk factors.

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