Correlation between 6q25.3 deletion status and survival in pediatric intracranial ependymomas

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• 作者：Camelia-Maria Monoranu ; Bei Huang ; Inna Lukashova-v. Zangen ; Stefan Rutkowski ; Giles Hamilton Vince ; Nicolas U. Gerber ; Bernhard Puppe ; Wolfgang Roggendorf
• 关键词：Klein-Gordon lattices ; Breather-modes ; Statistical physics ; Persistence distributions
• 刊名：Cancer Genetics and Cytogenetics
• 出版年：2008
• 期刊代码：43_01654608
• 类别：med
• 出版时间：1 April 2008
• 卷：182
• 期：1
• 页码：18-26
• 文件大小：783 K

摘要

There were 76 cases of DSM-III-R schizophrenia by age 28 years. Mothers' demographics were similar in cases and controls but conditions associated with chronic fetal hypoxia were more common in schizophrenia (OR 2.2; 1.3, 3.7), as were maternal fever above 38°C during pregnancy (OR 3.7; 0.7, 18.1), and placental ablations (OR 10.7; 1.8, 65). Delivery abnormalities were not more common in schizophrenia. Low birth weight (< 2.500 g), short gestation (< 37 weeks) and their combination (OR 3.4; 1.2, 9.5) were all more common in schizophrenia, but being small for gestational age (< 10th centile) was not; babies destined for schizophrenia tended to be born early but at an appropriate weight. 6 of 132 babies (4.6%) who survived perinatal brain damage developed schizophrenia (OR 7.5; 3.2, 17.6); 6.8%(5.4%, 7.4%) of the illness may be attributable to such damage.

The time window during which aberrations of brain development might contribute to the development of schizophrenia appears to be wider than previously proposed although, as in cerebral palsy, obstetric mishap does not appear important. We cannot rule out an interaction between pregnancy and perinatal events and a genetic diathesis.