Susceptibility of recent Canadian influenza A and B virus isolates to different neuraminidase inhibitors

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• 作者：Boivin ; Guy ; Goyette ; Nathalie
• 关键词：Influenza B ; Inhibitors ; Virus ; Influenza A
• 刊名：Antiviral Research
• 出版年：2002
• 期刊代码：7_01663542
• 类别：imm
• 出版时间：June, 2002
• 卷：54
• 期：3
• 页码：143-147
• 文件大小：71.4 K

摘要

Forty-two influenza A and 23 influenza B isolates collected from untreated subjects during the 1999–2000 influenza season in Canada were tested for their susceptibility to three neuraminidase inhibitors (zanamivir, oseltamivir carboxylate and RWJ-270201 or BCX-1812) using a chemiluminescent neuraminidase assay. Influenza B isolates were less susceptible than A viruses to all tested drugs. RWJ-270201 was the most potent drug against both influenza A(H3N2) (mean IC₅₀: 0.60 nM) and B (mean IC₅₀: 0.87 nM) viruses. Oseltamivir carboxylate was more active than zanamivir for influenza A(H3N2) isolates (mean IC₅₀: 0.73 vs. 2.09 nM) whereas it was less potent against B viruses (mean IC₅₀: 11.53 vs. 4.15 nM).