Feasibility of ⁹⁹Mo production by proton-induced fission of ²³²Th

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• 作者：Kamel Abbas^a ; ^{kamel.abbas@jrc.ec.europa.eu} ; Uwe Holzwarth^a ; Federica Simonelli^a ; Jan Kozempel^a ; Izabela Cydzik^a ; Antonio Bulgheroni^a ; Giulio Cotogno^a ; Christos Apostolidis^b ; Frank Bruchertseifer^b ; Alfred Morgenstern^b
• 关键词：99Mo ; 99mTc ; 232Th ; Excitation function ; Stacked-foil technique ; Cyclotron
• 刊名：Nuclear Instruments and Methods in Physics Research Section B ; Beam Interactions with Materials and Atoms
• 出版年：2012
• 期刊代码：42_0168583x
• 类别：ph
• 出版时间：1 May, 2012
• 卷：278
• 期：Complete
• 页码：20-25
• 文件大小：399 K

摘要

The current global crisis in supply of the medical isotope generator ⁹⁹Mo/^99mTc has triggered much research into alternative non-reactor based production methods for ⁹⁹Mo including innovative radionuclide production techniques using ion accelerators. A novel method is presented here that has thus far not been considered: ²³²Th is used as target material to produce carrier-free ⁹⁹Mo for ⁹⁹Mo/^99mTc generators by proton-induced fission (²³²Th (p, f) ⁹⁹Mo). The thick target yields of ⁹⁹Mo are estimated as 3.6 MBq/渭A路h and 21 MBq/渭A路h for proton energies of 22 MeV and 40 MeV, respectively, energies that are available from many cyclotrons. With respect to ⁹⁹Mo reactor based methods using uranium targets, the presented concept using ²³²Th does not pose proliferation concerns, transport of highly radioactive target materials can be reduced and unused cyclotron capacities could be exploited. Radiochemical target processing could be based on existing technologies of extraction of ⁹⁹Mo from reactor irradiated ²³⁵U. The presented method could be used for co-production of other radioisotopes of medical interest such as ¹³¹I.