Dancing with the sterols: Critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis

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• 作者：Elizabeth J. Tarling ; Peter A. Edwards ; ^{pedwards@mednet.ucla.edu}
• 关键词：ABC ; ATP Binding Cassette ; AICAR ; Aminoimidazole Carboxamide Ribonucleotide ; ApoE ; Apolipoprotein E ; ApoER2 ; ApoE receptor 2 (LRP8) ; AR ; Androgen Receptor ; BAC ; Bacterial Artificial Chromosome ; CETP ; Cholesterol Ester Transfer Protein ; eNOS ; endothelial N
• 刊名：Biochimica et Biophysica Acta (BBA)/Molecular and Cell Biology of Lipids
• 出版年：2012
• 期刊代码：18_13881981
• 类别：bio
• 出版时间：March, 2012
• 卷：1821
• 期：3
• 页码：386-395
• 文件大小：658 K

摘要

ATP binding cassette (ABC) transporters represent a large and diverse family of proteins that transport specific substrates across a membrane. The importance of these transporters is illustrated by the finding that inactivating mutations within 17 different family members are known to lead to specific human diseases. Clinical data from humans and/or studies with mice lacking functional transporters indicate that ABCA1, ABCG1, ABCG4, ABCG5 and ABCG8 are involved in cholesterol and/or phospholipid transport. This review discusses the multiple mechanisms that control cellular sterol homeostasis, including the roles of microRNAs, nuclear and cell surface receptors and ABC transporters, with particular emphasis on recent findings that have provided insights into the role(s) of ABCG1. This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010).