A1C was measured in 511 subjects (mean age of 52.4 years; range 14-93) undergoing the 75-g oral glucose tolerance test (OGTT). Using receiver operating curve (ROC) analysis, the performance of A1C for the diagnosis of diabetes (using different standard criteria) was compared between 4 groups: < 45 (n = 156), 45-54 (n = 132), 55-64 (n = 122), 鈮?#xA0;65 years (n = 101).
Subjects aged 鈮?#xA0;65 years had the highest false-negative rates with fasting plasma glucose (60.8%) and A1C (35.1%), the smallest area under ROC curve (0.723, 95%CI 0.627-0.820), the lowest sensitivity (58.7%, 95%CI 50.4-65.7) and specificity (71.1%, 95%CI 57.3-82.6) of A1C 6.5%, compared to the younger age groups.
OGTT is preferable for diagnosis of DM in older Southeast Asian adults.