Oral administration of docosahexaenoic acid attenuates interleukin-1尾 response and clinical course of septic neonates

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• 作者：Mardia Ló ; pez-Alarcó ; n ; M.D. ; Ph.D.^a ; ^{marsau2@prodigy.net.mx} ; Mariela Bernabe-Garcí ; a ; M.Sc.^a ; Olivia del Valle ; M.D.^b ; Gabriel Gonz&aacute ; lez-Moreno ; M.D.^a ; Azucena Martí ; nez-Basilea ; M.D.^a ; Raú ; l Villegas ; M.D.^b
• 关键词：Long-chain polyunsaturated fatty acids 蠅-3 ; Illness severity ; Sepsis ; Leucocytes
• 刊名：Nutrition
• 出版年：2012
• 期刊代码：81_08999007
• 类别：abs
• 出版时间：April, 2012
• 卷：28
• 期：4
• 页码：384-390
• 文件大小：295 K

摘要

Objective

To analyze cytokine responses and the clinical course of septic neonates orally supplemented with docosahexaenoic acid as well as to evaluate fatty acid incorporation into leukocytes.

Methods

A quasiexperimental study was conducted in neonates who developed sepsis following a surgical procedure. Selected neonates were randomly assigned to receive 100 mg docosahexaenoic acid (G-DHA) daily or olive oil (G-OO) as placebo for 14 d throughout a sepsis episode. At selection (baseline), blood samples were obtained to determine interleukin-1 (IL-1)尾, interleukin-6 (IL-6), and tumor necrosis factor-伪 as well as the leucocyte fatty acid profile. Measurements were repeated at 7 (D7) and 14 d (D14) of follow-up. Within- and between-group comparisons were conducted with parametric statistics after logarithmic transformation. Repeated measurement analyses with a general linear model procedure were used, adjusting according to human milk intake, use of anti-inflammatory drugs, and nutritional status.

Results

Sixty-three neonates were included: 29 in G-DHA group and 34 in G-OO group. Although decreases of cytokines during hospitalization were similar in both groups, there was a greater decrease of IL-1尾 in the G-DHA group than in the G-OO group after adjusting by confounders (m>Pm>聽=聽0.028). Leukocyte docosahexaenoic acid increased from 4.96 卤 2.96 at baseline to 5.52 卤 3.05 and 5.92 卤 2.8 at D7 and D14, respectively, in the G-DHA group (m>Pm> = 0.044). Illness severity was聽inversely associated with the proportion of docosahexaenoic acid in leukocytes throughout follow-up (m>Pm> = 0.034).

Conclusions

Oral supplementation with docosahexaenoic acid to neonates attenuates IL-1尾 response and the clinical course of sepsis. This may be an additional strategy to further benefit ill neonates even if they are not candidates for parenteral nutrition.