Clinical response to chemotherapy in locally advanced breast cancer was not associated with several polymorphisms in detoxification enzymes and DNA repair genes

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• 作者：Mostafa Saadat^a ; ^{msaadat41@yahoo.com} ; ^{saadat@susc.ac.ir} ; Maryam Khalili^a ; Meysam Nasiri^a ; Mehrdad Rajaei^a ; Shahpour Omidvari^b ; Iraj Saadat^a
• 关键词：Breast cancer ; Polymorphism ; Response to chemotherapy
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2012
• 期刊代码：159_0006291x
• 类别：bio
• 出版时间：2 March, 2012
• 卷：419
• 期：1
• 页码：117-119
• 文件大小：154 K

摘要

The main aim of the present study was to investigate the association between several genetic polymorphisms (in glutathione S-transferase members and DNA repair genes) and clinical response to chemotherapy in locally advanced breast cancer. A sequential series of 101 patients were prospectively included in this study. Clinical assessment of treatment was accomplished by comparing initial tumor size with preoperative tumor size using revised RECIST guideline (version 1.1). Clinical response was regarded as a response or no response. There was no difference between non-responders and responders for the prevalence of genotypes of the study polymorphisms.