Differential cigarette-related startle cue reactivity among light, moderate, and heavy smokers

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• 作者：Yong Cui^a ; ^b ; Jason D. Robinson^c ; Francesco Versace^c ; Cho Y. Lam^c ; Jennifer A. Minnix^c ; Maher Karam-Hage^c ; John A. Dani^a ; ^b ; Thomas R. Kosten^a ; ^b ; David W. Wetter^d ; Victoria L. Brown^c ; Paul M. Cinciripini^c ; ^{pcinciri@mdanderson.org}
• 关键词：Cue reactivity ; Affect ; Nicotine addiction ; Startle response
• 刊名：Addictive Behaviors
• 出版年：2012
• 期刊代码：2_03064603
• 类别：psy
• 出版时间：August, 2012
• 卷：37
• 期：8
• 页码：885-889
• 文件大小：261 K

摘要

In this study, we examined the relationship between the level of daily cigarette consumption and the startle response to affective and cigarette-related cues among treatment-seeking smokers. Before receiving any behavioral or pharmacological treatment, 136 smokers attended a baseline laboratory session, during which we recorded their reflexive eyeblink responses to acoustic startle probes while they were viewing pleasant, unpleasant, neutral, and cigarette-related pictures. We found that 1) cigarette-related and pleasant pictures similarly reduced the startle magnitude compared to neutral pictures; 2) the magnitude of startle modulation rendered by pleasant or unpleasant pictures did not differ among light, moderate, and heavy smokers; and 3) startle attenuation by cigarette-related pictures was greater in heavy smokers than in light smokers. These results suggest that similar to pleasant stimuli, cigarette-related cues are motivationally salient for smokers, and that this salience increases with nicotine dependence.