Thrombosis and Acute coronary syndrome
- 作者：Rosanna Abbate ; Gabriele Cioni ; gabriele.cioni@unifi.it ; Ilaria Ricci ; Marco Miranda ; Anna Maria Gori
- 关键词：(ACS) ; Acute coronary syndrome ; (Lp-PLA2) ; lipoprotein-associated phospholipase A2 ; (TXA2) ; thromboxane A2 ; (PAF) ; platelet activating factor ; (ADP) ; adenosine 5-diphosphate ; (NO) ; nitric oxide ; (vWF) ; von Willebrand factor ; (TF) ; tissue factor ; (or TFPI)
- 刊名：Thrombosis Research
- 出版年：2012
- 期刊代码：247_00493848
- 类别：med
- 出版时间：March, 2012
- 卷：129
- 期：3
- 页码：235-240
- 文件大小：339 K
摘要
Acute coronary syndromes (ACS) represent the main clinical manifestation of atherosclerotic progression in the coronary district. Thrombosis plays a critical role in the patho-anatomical of ACS, as disruption of an atherosclerotic plaque exposes flowing blood to subendothelial collagen, tissue factor, and other procoagulant molecules that trigger activation of platelets and formation of fibrin within the vessel lumen.
Endothelial damage/dysfunction, inflammation and coagulation are closely related to the pathophysiology of ACS and may be inter-related.
Platelets play key roles in both the formation of the atheromatous plaque and clinical presentation of acute atherothrombotic events following plaque rupture. In the pathogenesis of the ACS, blood clotting activation has a crucial role and thrombin generation and TF may represent useful markers for the identification of patients at high risk of vascular events. Lipoprotein-associated phospholipase A2 (Lp-PLA2) represents the crossroads between lipid metabolism and inflammatory response.