Acute toxicity of manganese in goldfish Carassius auratus is associated with oxidative stress and organ specific antioxidant responses
- 作者：Maria Conceiç ; ao Vieira mcvlacerda@terra.com.br ; Rafael Torronteras torronte@uhu.es ; Francisco Có ; rdoba fcordoba@uhu.es ; Antonio Canalejo ; antonio.canalejo@dbasp.uhu.es
- 关键词：Fish ; Freshwater environment ; Heavy metal ; Lipid peroxidation ; Manganese ; Oxidative stress
- 刊名：Ecotoxicology and Environmental Safety
- 出版年：2012
- 期刊代码：77_01476513
- 类别：env
- 出版时间：1 April, 2012
- 卷：78
- 期：Complete
- 页码：212-217
- 文件大小：252 K
摘要
Manganese is a relatively common, yet poorly studied element in freshwater ecosystems, where it can be significantly bioconcentrated. The knowledge about the mechanisms of Mn toxicity on fish health is still limited. The aim of the present study was to assess the potential induction of oxidative stress and the antioxidant response after a 96 h waterborne Mn-exposure (at 0.1 and 1 mM) in gill, kidney, liver and brain of goldfish (Carassius auratus). Mn 1 mM induced an increase of lipid hydroperoxides, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in all tissues with the exception of SOD inhibition in the brain. Particular response of catalase (CAT) was indicated鈥攊ts inhibition in the liver and kidney, but activation in the gill. Exposure to Mn 0.1 mM provoked most prominent changes in the liver and did not change the indexes in brain. These results strongly suggest that Mn exposure caused a generalized oxidative stress in the fish and revealed an organ specific antioxidant response involving a differential modulation of the SOD, CAT and GPx activities.