Stratigraphic data reveal a remarkable difference between the architecture of the northern and southern volcano sectors that is compatible with the occurrence of the DA1 debris avalanche in the southern volcano sector. A contour map and a three-dimensional model of a surface merging the morphology of the top of the Somma lavas, in the northern volcano sector, with that of the top of the DA1 debris avalanche, in the southern volcano sector, were reconstructed. We present a new lateral collapse model of Vesuvius Volcano and document the relevance of inherited tectonic faults in guiding collapse geometry. It is possible that the SW-directed collapse (DA1) was driven towards the hangingwall blocks of NW-SE normal faults, while the propagation of the W-directed collapse (DA2) can be ascribed to the activity of the E-W strike-slip fault. Because of their distal location a minor role of cryptodome intrusion on collapses of Vesuvius can be postulated. The detailed analysis of substrate and edifice structure presented here establishes clear connexion between substrate tectonics and lateral collapse. This approach broadens the horizons of volcanic hazard assessment of Vesuvius.