Piezoelectric pumping in flow analysis: Application to the spectrophotometric determination of gabapentin
- 作者：Marta F.T. Ribeiro ; Joã ; o L.M. Santos ; José ; L.F.C. Lima
- 关键词：Piezoelectric micro-pump ; Flow analysis ; Pulsed flow ; Gabapentin ; 1 ; 2-Naphthoquinone-4-sulfonate ; Multi-pumping
- 刊名：Analytica Chimica Acta
- 出版年：2007
- 期刊代码：2_00032670
- 类别：ch
- 出版时间：26 September 2007
- 卷：600
- 期：1-2
- 页码：14-20
- 文件大小：232 K
摘要
Solutions propelling devices are fundamental components of a flow-based analytical manifold. In this work different manifold configurations were implemented to evaluate the performance of multiple piezoelectric micro-pumps used as solutions insertion and propulsion devices. The micro-pumps are piezo-actuated micro-diaphragm pumps with passive check valves characterised by a small compact size and low power demands, and are able to produce reproducible flow rates of up to 4 mL min−1. The flow rate is controlled by the frequency of the piezoelectric actuator (up to 20 Hz). As an additional feature, piezoelectric micro-pumps actuation generates a pulsed flowing stream that ensures a faster sample/reagent mixing contributing to improved reaction development.
The developed flow approach was assessed in the spectrophotometric determination of gabapentin in pharmaceutical preparations upon reaction with 1,2-naphthoquinone-4-sulfonate in alkaline medium. Distinct flow manifold configurations were designed for achievement of different solutions management. Linear calibrations plots for gabapentin concentrations of up to 150 mg L−1, with relative standard deviations of less than 1.50%(n = 10) and a sample throughput of about 28 determinations per hour, were obtained.