High efficiency Hall effect micro-biosensor platform for detection of magnetically labeled biomolecules
- 作者：Adarsh S ; hu ; Yoshimichi Kumagai ; Adam Lapicki ; Satoshi Sakamoto ; Masanori Abe ; Hiroshi H ; a
- 关键词：Hall effect ; Magnetic field sensor ; Magnetic labels ; Superparamagnetic beads ; Electromagnetic field effects
- 刊名：Biosensors and Bioelectronics
- 出版年：2007
- 期刊代码：12_09565663
- 类别：ch
- 出版时间：15 April 2007
- 卷：22
- 期：9-10
- 页码：2115-2120
- 文件大小：766 K
摘要
Detection of magnetically labeled biomolecules using micro-Hall biosensors is a promising method for monitoring biomolecular recognition processes. The measurement efficiency of standard systems is limited by the time taken for magnetic beads to reach the sensing area of the Hall devices. Here, micro-current lines were integrated with Hall effect structures to manipulate the position of magnetic beads via field gradients generated by localized currents flowing in the current lines. Beads were accumulated onto the sensor surface within seconds of passing currents through the current lines. Real-time detection of magnetic beads using current lines integrated with Hall biosensors was achieved. These results are promising in establishing Hall biosensor platforms as efficient and inexpensive means of monitoring biomolecular reactions for medical applications.