Temporal pattern of locomotor activity recuperation after administration of propofol in Japanese quail (Coturnix coturnix japonica)

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• 作者：J.M. Kembro^a ; ^b ; D.A. Guzman^a ; M.A. Perillo^a ; ^b ; R.H. Marin^a ; ^b ; ^{rmarin@efn.uncor.edu}
• 关键词：Open-field ; Fractal analysis ; Ambulation ; Detrended fluctuation analysis ; Frequency distribution of events
• 刊名：Research in Veterinary Science
• 出版年：2012
• 期刊代码：272_00345288
• 类别：med
• 出版时间：August, 2012
• 卷：93
• 期：1
• 页码：156-162
• 文件大小：301 K

摘要

The present study evaluates the organization and complexity of the temporal pattern of locomotion after an acute administration of propofol in Japanese quail by using traditional and fractal analysis. Birds were administered with propofol 0, 10, 20, 40 or 80 mg/kg. Ten min after administration, they were placed in an open-field apparatus and their locomotor activity was recorded during 45 min at a resolution of 0.5 s. A significant dose dependant increase in the latency to initiate ambulation was observed for doses of 20, 40 and 80 mg/kg when compared to the control group. A rapid recuperation of normal locomotor activity was observed after sedation with 20 mg/kg. Birds administered with propofol 40 mg/kg showed signs of recuperation of normal locomotion after 30 and 40 min (males and females, respectively) of propofol administration, that was not observed in quail treated with propofol 80 mg/kg. Our results suggest that depending on the dose, propofol administration in quail may allow full locomotor recovery of a sedative/anesthetic dose as early as 30 min post-administration.