Fast and selective oxidation of thioglycosides to glycosyl sulfoxides using KF/m-CPBA

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• 作者：Geetanjali Agnihotri and Anup Kumar Misra
• 关键词：Glycosyl sulfoxide ; Thioglycoside ; KF ; m-CPBA ; Selective ; Fast
• 刊名：Tetrahedron Letters
• 出版年：2005
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：2005
• 卷：46
• 期：47
• 页码：8113-8116
• 文件大小：105 K

摘要

A very fast and selective oxidation of thioglycosides to glycosyl sulfoxides has been achieved using KF/m-CPBA in CH₃CN–H₂O. This protocol has many advantages compared to the currently available methodologies for this transformation in terms of selectivity, yield, reaction time, control of temperature, etc. The yields obtained were excellent in all cases.