Access to original spirocyclic derivatives via inter- or intramolecular reaction mediated by manganese(III) acetate

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• 作者：Ahlem Bouhlel^a ; Christophe Curti^a ; Michè ; le P. Bertrand^b ; Patrice Vanelle^a ; ^{patrice.vanelle@univ-amu.fr}
• 关键词：Manganese(III) acetate ; Spirocyclic derivatives ; Benzophenanthridinone ; Spirolactones
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：6 May, 2012
• 卷：68
• 期：18
• 页码：3596-3604
• 文件大小：569 K

摘要

An easily reproducible protocol allowing inter- or intramolecular spirocyclization on 尾-dicarbonyl structures is described. This methodology could afford a wide variety of spirocyclic pharmacophores. As examples, highly substituted spirobenzophenanthridin-6(5H)-ones and spirolactones were synthesized. These scaffolds could be used for the design of many compounds exhibiting biological activities.