Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT₇ receptor ligands

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• 作者：Magalie Paillet-Loilier ; Fré ; dé ; ric Fabis ; Alban Lepailleur ; Ronan Bureau ; Sabrina Butt-Gueulle ; Franç ; ois Dauphin ; Catherine Delarue ; Hubert Vaudry and Sylvain Rault
• 关键词：Phenylpyrrole ; Virtual screening ; 5-HT₇ receptor
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2005
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：2005
• 卷：15
• 期：16
• 页码：3753-3757
• 文件大小：229 K

摘要

Virtual screening studies have identified a series of phenylpyrroles as novel 5-HT₇ receptor ligands. The synthesis and the affinity for the 5-HT₇ receptor of these phenylpyrroles are described. Some of these compounds exhibited high affinity for the 5-HT₇ receptors.