Treatment of nonmetastatic and metastatic low-risk gestational trophoblastic neoplasia: Factors associated with resistance to single-agent methotrexate chemotherapy

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• 作者：Eloise Chapman-Davis^a ; Anna V. Hoekstra^a ; Alfred W. Rademaker^b ; Julian C. Schink^a ; John R. Lurain^a ; ^{jlurain@nmff.org}
• 关键词：Gestational trophoblastic neoplasia (GTN) ; Low-risk GTN ; Chemotherapy ; Methotrexate ; Actinomycin D
• 刊名：Gynecologic Oncology
• 出版年：2012
• 期刊代码：295_00908258
• 类别：med
• 出版时间：June, 2012
• 卷：125
• 期：3
• 页码：572-575
• 文件大小：145 K

摘要

Objective

To determine factors associated with resistance to methotrexate treatment of low-risk gestational trophoblastic neoplasia (GTN).

Methods

We reviewed the records of 358 patients with low-risk GTN (FIGO stage I and stages II-III, score < 7) treated initially with methotrexate 0.4 mg/kg (max 25 mg) IV push daily 脳 5 days every 14 days between 1979 and 2009. Actinomycin D 0.5 mg IV push daily 脳 5 days every 14 days was used in 64 patients who developed resistance or toxicity to initial methotrexate chemotherapy, and combination drug regimens were used in 20 patients who failed single-agent chemotherapy. Adjuvant surgery was used in 34 selected patients. Clinical response and survival as well as factors affecting outcomes were analyzed retrospectively.

Results

The complete response rate to initial methotrexate chemotherapy was 81%(290/358) and the complete response rate to actinomycin D as secondary therapy was 75%(48/64), for an overall complete response rate to sequential single-agent chemotherapy of 94%(338/358). The remaining 20 patients (6%) were all placed into permanent remission with the use of multiagent chemotherapy with or without surgery. Resistance to initial methotrexate chemotherapy was associated with increasing FIGO score (p < .0001), clinicopathologic diagnosis of choriocarcinoma (p = .028), higher pretreatment hCG (p = 0.001) and presence of metastatic, disease (p = .018).

Conclusions

Sequential single-agent chemotherapy with methotrexate (0.4 mg/kg-max 25 mg) followed by actinomycin D (0.5 mg) each given IV push for 5 consecutive days every other week for treatment of low-risk GTN resulted in only 6%of patients requiring multiagent chemotherapy and a 100%survival rate.