Allergen-specific responses of CD19(+)CD5(+)Foxp3(+) regulatory B cells (Bregs) and CD4(+)Foxp3(+) regulatory T cell (Tregs) in immune tolerance of cow milk allergy of late eczematous reactions

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• 作者：Joonyong Noh^a ; Geunwoong Noh^b ; ^{admyth@naver.com} ; Hyuk Soon Kim^c ; A.-Ram Kim^c ; Wahn Soo Choi^c ;
• 关键词：Foxp3 ; Regulatory B cell ; Regulatory T cell ; Food allergy ; CD5(+) B ; Milk allergy ; Non-IgE-mediated food allergy ; Atopic dermatitis
• 刊名：Cellular Immunology
• 出版年：2012
• 期刊代码：279_00088749
• 类别：med
• 出版时间：2012
• 卷：274
• 期：1-2
• 页码：109-114
• 文件大小：617 K

摘要

Foxp3-expressing cells among CD19(+)CD5(+) B cells were identified as regulatory B cells. Food allergy manifesting as late eczematous reactions is regarded as a non-IgE-mediated food allergy. The diagnosis for milk allergy manifesting as late eczematous reactions was made on the basis of the findings obtained from a double-blind placebo-controlled food challenge in patients with atopic dermatitis. Twelve patients with milk allergy and 12 patients who could tolerate milk were selected. On casein stimulation, the CD19(+)CD5(+)Foxp3(+) B cell (Breg) fraction in CD5(+) B cells decreased from 4.4 卤 1.1%to 3.1 卤 0.7%(P = 0.047, n = 12) in the milk allergy group and increased from 4.4 卤 1.3%to 5.2 卤 1.4%(P = 0.001, n = 10) in the milk-tolerant group. On the other hand, on allergen stimulation, the number of CD4(+)Foxp3(+) regulatory T cells (Tregs) in the milk allergy group and milk-tolerant group increased from 2.6 卤 0.7%to 3.4 卤 0.6%(P = 0.014, n = 9) and from 2.7 卤 1.0%to 3.5 卤 1.0%(P = 0.038, n = 10), respectively. In conclusion, allergen-specific responses of Bregs, rather than those of Tregs, seem to influence the immune responses (i.e., allergy or tolerance) to a food allergen.