Feeling the Squeeze: Live-Cell Extrusion Limits Cell Density in Epithelia

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• 作者：Rodrigo Fernandez-Gonzalez¹ ; ² ; Jennifer&#160 ; A. Zallen³ ; ^{zallenj@mskcc.org}
• 刊名：Cell
• 出版年：2012
• 期刊代码：50_00928674
• 类别：med
• 出版时间：25 May, 2012
• 卷：149
• 期：5
• 页码：965-967
• 文件大小：213 K

摘要

Tissues develop in confined volumes that can impose mechanical constraints on their growth, but it is unclear how cells respond to these limits to regulate tissue size and shape. Two papers show that overcrowding and cell deformation lead to the shedding of live cells to maintain homeostasis in epithelial cell sheets.