Skeletal diversity via Pd(0) catalysed three-component cascades of allene and halides or triflates with protected hydroxylamines and formamide

详细信息	查看全文 | 推荐本文 |

• 作者：Elghareeb E. Elboray ; Chuanjun Gao ; Ronald Grigg ; ^{r.grigg@leeds.ac.uk}
• 关键词：Mono- and di-protected hydroxylamines ; Catalytic cascades ; Aryl/heteroaryl bromides ; Iodides ; Triflates ; Iodouracil
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：8 April, 2012
• 卷：68
• 期：14
• 页码：3103-3111
• 文件大小：3824 K

摘要

The reactions of allene gas (1 atm) and of 1,1-dimethylallene with a range protected hydroxylamines and formamide with aryl/heteroaryl iodides, bromides and triflates under Pd(0) catalysis lead to a skeletally diverse range of products in good yield. The cascades tolerate both electron withdrawing and electron donating substrates and 1,1-dimethylallene reacts regioselectively in all cases.