Nitric oxide metabolites in allergic rhinitis: The effect of pollen allergen exposure

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• 作者：G. Ciprandi^a ; ^{gio.cip@libero.it} ; M. Tosca^b ; D. Fuchs^c
• 关键词：Allergic rhinitis ; Serum ; Nitrite ; Pollen allergen exposure
• 刊名：Allergologia et Immunopathologia
• 出版年：2011
• 期刊代码：pca44_03010546
• 类别：med
• 出版时间：November-December 2011
• 卷：39
• 期：6
• 页码：326-329
• 文件大小：201 K

摘要

Background

Seasonal allergic rhinitis (SAR) is characterised by an inflammation consequent to allergen exposure. Nitric oxide may be involved in allergic inflammation.

Objective

This study evaluated the serum nitrite concentrations in SAR patients during and outside pollen exposure in order to estimate activity of nitric oxide synthases.

Methods

One hundred and two (56 females, 46 males, median age: 28.7 years) were included in this study: 56 with SAR evaluated outside the pollen season and so without allergic inflammation and symptoms, and 46 with SAR evaluated during the pollen season with symptoms. Serum concentrations of nitrite were measured and in those patients exposed to pollens, results were compared to scores of the Visual Analogue Scale for nasal obstruction perception.

Results

Serum nitrite concentrations were higher in SAR patients evaluated outside the pollen season (U = 鈭?.78; p < 0.0001), moreover, there was a significant relationship between nasal obstruction perception and nitrite in patients evaluated during the pollen season.

Conclusion

This preliminary study demonstrates that serum nitric oxide metabolism depends on allergen exposure.