Reduction of propargylic sulfones to (Z)-allylic sulfones using zinc and ammonium chloride

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• 作者：Helen M. Sheldrake ; Timothy W. Wallace
• 关键词：Propargylic sulfone ; Allylsulfone ; cis-Hydrogenation ; Reduction ; Zinc
• 刊名：Tetrahedron Letters
• 出版年：2007
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：18 June 2007
• 卷：48
• 期：25
• 页码：4407-4411
• 文件大小：159 K

摘要

Propargylic sulfones can be cis-hydrogenated using commercial zinc powder and ammonium chloride in THF–water at room temperature, the major products being the corresponding (Z)-allylic sulfones. Other reducible groups (alkene, benzyloxy) are not affected. Allenylsulfones are implicated in one of the possible reaction pathways.