Urine and extragenital gonococcal and Chlamydia infections in HIV positive young men who have sex with men (YMSM): enhanced detection of rectal Chlamydia when screening with nucleic acid amplified tests versus cultures

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• 作者：Natalie Neu ; MD ; MPH^a ; John Nelson ; PhD ; CPNP^b ; ^{jon9018@nyp.org} ; Elizabeth Ranson ; BA^a ; Susan Whittier ; PhD^b ; Amy Shaw ; BA^a ; Alwyn Cohall ; MD^a
• 关键词：Sexually transmitted diseases ; Diagnostic testing
• 刊名：Journal of Men's Health
• 出版年：2012
• 期刊代码：P97_18756867
• 类别：med
• 出版时间：June, 2012
• 卷：9
• 期：2
• 页码：89-93
• 文件大小：130 K

摘要

Background

Multiple studies have been done on adult men who have sex with men (MSM), but no studies have shown the rates of extragenital site sexually transmitted infections (STIs) among HIV positive young men who have sex with men (YMSM). The objective of this study was to document the rates of extragenital Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) infection among HIV positive YMSM while conducting a validity study for the use of nucleic acid amplified tests (NAATs), to detect extragenital GC and CT.

Methods

Behaviorally infected HIV positive YMSM were enrolled in this study from one urban adolescent HIV clinic, and were screened for urine and extragenital site GC and CT over a 2 year period. Samples from these sites (pharyngeal and rectal) were tested for GC and CT using both traditional culture media and NAAT technology. Urine was tested using only NAAT.

Results

Of 67 screenings, 36%(n = 24) yielded at least one positive, and 69%of participants (18/26) had at least one positive GC or CT test result during the study period. Of those with at least one positive result, 89%(16/18) had at least one extragenital site infection. Urine testing was positive in 11%(2/18) of those with a corresponding extragenital site infection. None of the extragenital CT infections detected by NAATs were detected by culture, and only 38%(5/13) of the extragenital GC infections detected by NAATs were detected by culture.

Conclusions

Use of NAATs for extragenital STI screening yielded more confirmed positive results than did traditional cultures. By use of NAATs, the majority of routinely screened HIV positive YMSM in this sample was found to have an STI at an extragenital site.